SRP® Ready To Take On Salmonella

Unique SRP vaccine technology offers new approach to kill harmful salmonella bacteria. 

With over 2,400 serotypes of salmonella bacteria inexistence, controlling clinical and subclinical
salmonella shedding among cattle has often been challenging. But a more effective vaccine to fight these costly bacterial pathogens is now available with the recent development of SRP® vaccine technology, which was granted a USDA conditional license this fall. SRP technology provides broader protection from bacterial disease infection because it uses purified extracts of siderophore receptors and porins (SRPs), highly specialized proteins found on the cell wall of gram-negative bacteria, such as salmonella.
 
These SRPs are virtually identical in structure and function among different salmonella serotypes,
and have been shown to be cross-reactive in laboratory studies. This is an important difference
compared to traditional bacterial vaccines which are developed with whole-cell vaccine production
methods that can only provide strain-specific protection against a particular serotype.
Blocking Bacteria’s Source of Iron
SRP technology’s successful mode of action to control salmonella hinges on its ability to deprive bacteria of iron. Iron is an essential nutrient for the life, health and reproduction of bacteria like salmonella. Without it the bacteria die. Here’s how it works:
 
  • SRPs are specialized iron-transport proteins found on the cell wall of the salmonella bacteria.
  • When injected into the animal, SRPs stimulate the production of antibodies that block the siderophore receptors and porins.
  • This prevents the transport of essential iron into the bacteria causing a bacteriocidal effect on the salmonella organism.
  • SRPs are identical on multiple serotypes of salmonella. Laboratory studies have demonstrated the cross reactive nature of these SRPs across various different salmonella strains.
Additionally, unlike core antigen bacterins, SRP vaccines are made with purified proteins, so they
contain very low amounts of endotoxin, which minimizes post-vaccination reactions.
Now Available
SRP technology is a better way to make vaccines with superior effectiveness and safety. With USDA
approval of a conditional license this fall, the SRP® Salmonella Newport Bacterial Extract vaccine from AgriLabs is now available through your local veterinarian or animal health distributor.