Major breakthroughs help control costly clinical salmonellosis.

The incidence of salmonella bacteria is high. Salmonella bacteria are present on nearly all dairy farms. Statistics show that the incidence of salmonellosis on dairy farms has increased dramatically in recent years,with more than 15 percent of cows now testing positive for the bacteria. More and more, there is a potential for either a costly salmonella outbreak or an insidious, profit-robbing subclinical infection.
Scientists have identified nearly 2,400serotypes of salmonella bacteria and each of them can cause disease in both cattle and humans. 
Salmonella infections can be devastating and costly.
Salmonella infections pose a severe health risk to all cattle, especially young dairy calves, growing heifers and cows in the first 30 days of their lactation. Severe cases of salmonellosis in calves and cowsare very difficult to treat and can result in a high death loss. In most cases, the bacteria enter the calves’ digestive systems orally, shortly after birth. Exposure can come from contaminated calving pens or from an infected dam. 
SRP® is now ready to take on salmonella.
Now, a more effective vaccine is available to fight these costly bacterial pathogens, with the recent development of SRP vaccine technology, which was granted a USDA conditional license in fall of 2004.
SRP technology provides excellent protection from bacterial disease infection because it uses purified extracts of siderophore receptors and porins (SRPs), highly specialized proteins found on the cell wall of gram negative bacteria, such as salmonella.
 
These SRPs are virtually identical in structure and function among different salmonella serotypes and have been shown to be cross-reactive in laboratory studies. This is an important difference compared to traditional bacterial vaccines which are developed with whole-cell vaccine production methods that can only provide strain-specific protection against a particular serotype. 
Blocking bacteria’s source of iron.
SRP technology’s successful mode-of-action to control salmonella hinges on its ability to deprive bacteria of iron. Iron is an essential nutrient for the life, viability and reproduction of bacteria like salmonella. Without it, the bacteria die. Here’s how it works: 
  • SRPs are specialized iron-transport proteins found on the cell wall of the salmonella bacteria.
  • When injected into the animal, SRPs stimulate the production of antibodies that block the sidorophore receptors and porins.
  • This prevents the transport of essential iron into the bacteria, causing a bacteriocidal effect on the salmonella organism.
  • SRPs are identical on multiple serotypes of salmonella. Laboratory studies have demonstrated the cross reactive nature of these SRPs across various different salmonella strains.  
Additionally, unlike core antigen bacterins, SRP vaccines are made with purified proteins. So, they contain very low amounts of endotoxin, which minimizes post vaccination reactions. 

Now, a better way.

SRP technology is a better way to make vaccines with superior effectiveness and safety. With USDA approval of a conditional license, the SRP® Salmonella Newport Bacterial Extract vaccine from AgriLabs® is now available through your local veterinarian or animal health distributor. (Regulations for treatment with conditional use products vary by state. Consult your veterinarian for the availability of SRP technology in your area.)